Best Strategies and Ships for the Different Difficulties

This is my starting config for most games, using a carrier of course (at least 1 drone slot).
Right from the start, buy Bolter drones, upgrade their number.

You can now deal with most threats, and handle a single large ship with manual targetting. Save your money, then put 1 nuke at minimum.
You can go for one more nuke, or buy a support ship, that you'll equip with drones and nukes eventually.

You shouldn't need to buy lasers/shields at the beginning. Don't hesitate to sell weapons to acquire nukes and support ships easily.